A review on prevalence of angina pectoris in association with ccf (congestive cardiac failure) in gender and age-based population

Authors

  • Nossam Sameena B. Pharmacy, IV Year, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore District-524 346, Andhra Pradesh.
  • M. Sowjanya Assistant professor, Department of Pharmacy practice , Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore District-524 346, Andhra Pradesh.
  • Y Prapurna Chandra Principal and Professor, Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore District-524 346, Andhra Pradesh.
  • Venugopalaiah Penabaka Professor, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore District-524 346, Andhra Pradesh.
  • Afroz Patan Professor & HOD, Department of Pharmacy practice, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore District-524 346, Andhra Pradesh.

DOI:

https://doi.org/10.37022/jpmhs.v8i4.153

Keywords:

Angina pectoris, Congestive cardiac failure, Prevalence, Gender, Age, Ischemic heart disease

Abstract

Angina pectoris, one of the most characteristic symptoms of ischemic heart disease (IHD), remains a major cause of morbidity and mortality worldwide. It is typically presented as retrosternal chest pain, often radiating to the jaw, arms, or shoulders, and may be triggered by exertion, stress, or occur at rest in severe cases. The underlying mechanism involves an imbalance between myocardial oxygen demand and supply, primarily due to atherosclerotic obstruction, endothelial dysfunction, or coronary vasospasm. Over time, persistent ischemia and repeated episodes of angina may contribute to the development or worsening of congestive cardiac failure (CCF). CCF, defined as the inability of the heart to maintain adequate circulation, further complicates the clinical course of patients with angina, resulting in reduced quality of life and increased risk of adverse cardiovascular events. The present study emphasizes the prevalence of angina pectoris in association with CCF across different genders and age groups. Epidemiological data suggest that prevalence increases with advancing age, with men predominantly affected at younger ages, whereas women experience a higher burden after menopause. Risk factors such as hypertension, diabetes, obesity, dyslipidemia, and smoking further accelerate disease progression. Management involves a combination of lifestyle modifications, pharmacological therapy, and secondary prevention strategies. Beta-blockers, calcium channel blockers, nitrates, and novel anti-anginal agents remain the cornerstone of therapy, while risk factor modification plays a pivotal role in preventing disease progression. This study highlights the need for early diagnosis, gender- and age-specific risk stratification, and effective therapeutic interventions to reduce the burden of angina and its progression to heart failure. Ultimately, a better understanding of this association may improve patient outcomes and reduce cardiovascular mortality.

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References

Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease. J Am Coll Cardiol. 2014;64(18):1929–49.

Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non–ST-elevation acute coronary syndromes. Circulation. 2014;130(25):e344–426.

Bairey Merz CN, Pepine CJ, Walsh MN, Fleg JL. Ischemia and No Obstructive Coronary Artery Disease (INOCA). Circulation. 2017;135(11):1075–92.

Diamond GA, Forrester JS. Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. N Engl J Med. 1979;300(24):1350–8

Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41(3):407–77.

Yusuf S, Hawken S, Ôunpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (INTERHEART study). Lancet. 2004;364(9438):937–52.

Libby P. Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med. 2013;368(21):2004–13.

Canadian Cardiovascular Society. Classification of angina pectoris. Can Med Assoc J. 1976;115(6): 531–2.

Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease. Eur Heart J. 2013;34(38):2949–3003.

Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA 2002 guideline update for the management of unstable angina and non–ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2002;40(7):1366–74.

Libby P. Mechanisms of acute coronary syndromes. N Engl J Med. 2013;368(21):2004–13.

Taqueti VR, Di Carli MF. Coronary microvascular disease pathogenic mechanisms and therapeutic options. J Am Coll Cardiol. 2018;72(21):2625–41.

Lanza GA, Careri G, Crea F. Mechanisms of coronary artery spasm. Circulation. 2011;124(16):1774–82.

McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–726.

Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure. J Am Coll Cardiol. 2017;70(6):776–803.

Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2016;37(27):2129–200.

Gheorghiade M, Bonow RO. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation. 1998;97(3):282–9.

Fox K, Garcia MA, Ardissino D, et al. Guidelines on the management of stable angina pectoris. Eur Heart J. 2006;27(11):1341–81.

Yusuf S, Hawken S, Ôunpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study). Lancet. 2004;364(9438):937–52.

Eslick GD, Coulshed DS, Talley NJ. Review article: The burden of illness of non-cardiac chest pain. Aliment Pharmacol Ther. 2003;17(9):1211–9.

Maisch B, Seferović PM, Ristić AD, et al. Guidelines on the diagnosis and management of pericardial diseases. Eur Heart J. 2004;25(7):587–610.

Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105(9):1135–43.

Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41(3):407–77.

Beltrame JF, Crea F, Camici P. Advances in coronary microvascular dysfunction. Heart Lung Circ. 2009;18(1):19–27.

Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting–enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000;342(3):145–53.

Boden WE, O’Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356(15):1503–16.

Cholesterol Treatment Trialists’ (CTT) Collaborators. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes. Lancet. 2008;371(9607):117–25.

Cannon CP, Braunwald E, McCabe CH, et al. Intensive vs moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350(15):1495–504.

Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension. 2018;71(6):e13–115.

Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC Guidelines on the management of stable coronary artery disease. Eur Heart J. 2013;34(38):2949–3003.

Chaitman BR, Skettino SL, Parker JO, et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic angina. J Am Coll Cardiol. 2004;43(8):1375–82.

Chaitman BR. Medical treatment of chronic stable angina: evidence-based therapy. Am J Cardiol. 2002;89(9A):3–14.

Gibbons RJ, Balady GJ, Beasley JW, et al. ACC/AHA guidelines for exercise testing. J Am Coll Cardiol. 1997;30(1):260–311.

Bangalore S, Steg G, Deedwania P, et al. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA. 2012;308(13):1340–9.

Swedberg K, Komajda M, Böhm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT trial). Lancet. 2010;376(9744):875–85.

Roy D, Talajic M, Dorian P, et al. Amiodarone to prevent recurrence of atrial fibrillation. N Engl J Med. 2000;342(13):913–20.

Published

2025-10-23

How to Cite

Nossam, S., S. M, P. C. Y, V. Penabaka, and A. Patan. “A Review on Prevalence of Angina Pectoris in Association With Ccf (congestive Cardiac Failure) in Gender and Age-Based Population”. UPI Journal of Pharmaceutical, Medical and Health Sciences, vol. 8, no. 4, Oct. 2025, pp. 18-25, doi:10.37022/jpmhs.v8i4.153.

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Review Article(s)

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