https://uniquepubinternational.com/journals/index.php/jpmhs <div class="col-lg-9"> <div class="full-width"> <div id="pl-630" class="panel-layout"> <div id="pg-630-0" class="panel-grid panel-no-style"> <div id="pgc-630-0-1" class="panel-grid-cell"> <div id="panel-630-0-1-0" class="so-panel widget widget_sow-editor panel-first-child panel-last-child" data-index="2"> <div class="so-widget-sow-editor so-widget-sow-editor-base"> <div class="siteorigin-widget-tinymce textwidget"> <p>UPI Journal of Pharmaceutical Medical, and Health Sciences (UPI-JPMHS)-ISSN: 2581-4532 is a quarterly publishing, double-blind peer-reviewed, open access, international journal and invites papers from all the subjects/departments of pharmaceutical, medical, and health sciences.</p> </div> </div> </div> </div> </div> </div> </div> </div> South Asian Academic Publications en-US UPI Journal of Pharmaceutical, Medical and Health Sciences 2581-4532 <p><strong>Copyright © Author(s) retain the copyright of this article.</strong></p> https://uniquepubinternational.com/journals/index.php/jpmhs/article/view/121 <p>Bypassing the hepatic first pass metabolism and gaining direct access to systemic circulation through the internal jugular vein, buccal medication delivery offers great bioavailability. An appealing method of administration for systemic medication delivery is the buccal route. For the treatment of numerous illnesses, buccal bioadhesive films provide special benefits over conventional dosage forms by delivering topical medications into the oral cavity at a gradual and controlled rate. Reviewing recent advancements in the buccal adhesive drug delivery system, this essay aims to give young scientists fundamental concepts that will help them get around the challenges of formula creation. Bypassing the hepatic first pass metabolism and gaining direct access to systemic circulation through the internal jugular vein, buccal medication delivery offers great bioavailability. An appealing method of administration for systemic medication delivery is the buccal route. For the treatment of numerous illnesses, buccal bioadhesive films provide special benefits over conventional dosage forms by delivering topical medications into the oral cavity at a gradual and controlled rate. Reviewing recent advancements in the buccal adhesive drug delivery system, this essay aims to give young scientists fundamental concepts that will help them get around the challenges of formula creation.</p> Lakshmisavithri S Thangaballan B Bharath Kumar K M.Anwitha I Mithun Sukanya M Chennakesava Raju Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0 2025-03-18 2025-03-18 5 8 10.37022/jpmhs.v8i1.121 https://uniquepubinternational.com/journals/index.php/jpmhs/article/view/120 <p>Parabens are naturally occurring phenolic compounds commonly found in fruits such as blueberries and are valued for their antimicrobial and preservative properties. This study aims to extract parabens from blueberries and purify them using column chromatography. The extraction was carried out using a methanol-water solvent system (80:20 v/v) to maximize the yield of parabens. The crude extract was filtered and concentrated before further purification. Solvent partitioning with ethyl acetate was performed to enhance the separation of parabens from other non-polar compounds. The concentrated extract was subjected to column chromatography using silica gel as the stationary phase and a hexane-ethyl acetate gradient system as the mobile phase. Fractions were collected systematically and analyzed for the presence of parabens using Thin- Layer Chromatography (TLC), with standard parabens as reference markers. Selected fractions containing parabens were further validated using High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS) for confirmation and quantification. The results demonstrated successful extraction and isolation of parabens from blueberries, with efficient separation achieved using column chromatography. The findings can contribute to the development of natural preservatives for use in pharmaceutical, cosmetic, and food industries, offering an eco-friendly alternative to synthetic parabens.</p> Sruthi N Asma Parveen S Prapurna Chandra Y Copyright (c) 2025 https://creativecommons.org/licenses/by-nc/4.0 2025-02-17 2025-02-17 6 9 10.37022/jpmhs.v8i1.120