UPI Journal of Pharmaceutical, Medical and Health Sciences

Evaluation of hypolipidemic activity of hibiscus in high-fat diet-induced hyperlipidemia in wistar rats

2025-09-22T13:39:34-04:00

The global rise in obesity is largely linked to increased consumption of dietary fats, contributing to a higher prevalence of hyperlipidemia. This study aimed to evaluate the hypolipidemic activity of Hibiscus using an in vivo animal model. As current treatments like statins, though effective, are associated with potential side effects, there is growing interest in safer, plant-based alternatives. Hibiscus, a plant commonly found in India, is traditionally known for its lipid-lowering properties. The objective was to assess and compare the efficacy of an aqueous Hibiscus extract with Rosuvastatin in treating high-fat diet-induced hyperlipidemia in male Wistar rats. Hyperlipidemia was induced over 30 days, followed by a 30-day treatment period. Rats received Hibiscus extract orally at 2.5 g/kg and 5 g/kg, while the standard group received Rosuvastatin (10 mg/kg). Body weight, serum lipid profiles, and atherogenic indices were measured on days 0, 15, and 30. Data were analyzed using paired and unpaired Student’s t-tests. The Rosuvastatin group showed significant reductions in total cholesterol (TC), triglycerides (TG), LDL-C, and VLDL-C, along with increased HDL-C levels (p < 0.001). Hibiscus also produced significant but comparatively lower improvements in lipid parameters. Despite its lower efficacy, Hibiscus demonstrated a favorable safety profile and notable hypolipidemic effects, supporting its potential as a natural alternative in hyperlipidemia management. Further research is warranted to explore its mechanisms and long-term benefits.

Therapeutic potential of aerva lanata (mountain knotgrass) in the management of urinary tract infections

2025-09-26T10:40:31-04:00

Urinary tract infections (UTIs) are among the most common bacterial infections, affecting millions globally-especially women. The rising resistance to conventional antibiotics has encouraged the exploration of traditional medicinal plants as alternative therapies. Aerva lanata, commonly known as mountain knot grass, is a well-known herb in traditional Indian and African medicine, often used to treat kidney stones, urinary tract infections, and other urological conditions. This review aims to consolidate current research on the pharmacological properties of Aerva lanata. The plant is rich in phytochemicals such as flavonoids, alkaloids, tannins, saponins, and phenolic compounds, and it exhibits anti-inflammatory, diuretic, and anti-urolithiasis properties. While traditional use and preclinical studies support its therapeutic role in UTIs, further clinical trials are necessary to validate its efficacy, safety, and appropriate dosage in humans. This review brings together current scientific evidence and ethnomedical knowledge, highlighting Aerva lanata as a promising natural remedy for urinary tract infections

Soluplus - solid dispersion for enhanced drug delivery

2025-09-29T09:18:30-04:00

Many drugs have poor water solubility, which reduces their effectiveness. Solid dispersions are used to enhance the dissolution of such drugs. Soluplus, a polymer, improves drug solubility, prevents crystallization, and enhances absorption. It can be incorporated using techniques such as hot-melt extrusion, spray drying, and solvent evaporation. Incorporating Soluplus in solid dispersions improves drug performance and facilitates better bioavailability.