Synthesis, characterization and in-vitro anti-microbial activity of substituted 1,3,4-thiadiazole derivatives

Sivakumar Peta; Kavitha Pallepati

doi:10.37022/jpmhs.v8i1.159

Authors

Sivakumar Peta Associate Professor, Department of Pharmaceutical Chemistry, Gokula Krishna College of Pharmacy, Sullurupeta, Andhra Pradesh 524121.
Pallepati Kavitha Associate Professor, Department of Pharmaceutics, Gokula Krishna College of Pharmacy, Sullurupeta, Andhra Pradesh 524121.

DOI:

https://doi.org/10.37022/jpmhs.v8i1.159

Keywords:

Heterocyclic compounds, 1,3,4-Thiadiazoles, Purity of the compounds, laboratory conditions, antibacterial and antifungal

Abstract

Heterocyclic compounds possessing thiazole, thiadiazole or oxadiazole ring system show antifungal, bacteriostatic as well as antihelmintic effects. Compounds containing the above rings also exhibit antiinflammatory and antimicrobial properties and the depression effect on the central nervous system. Structure activity studies show that variations in ring system or minor group extend distinct pharmacological effect upon the drug molecules. 1,3,4-Thiadiazoles are biologically important group of compounds having activities like antibacterial, antifungal, antiinflammatory, diuretic, antiulcer, antihelmintic other biological activities. Melting points of newly synthesized compounds were determined by open capillary method and were uncorrected. Purity of the compounds was routinely checked by micro TLC. All the reactions were carried out under prescribed laboratory conditions. All the reactions were carried out under prescribed laboratory conditions. All the reactions requiring anhydrous conditions were conducted in well dried apparatus. All the synthesized compounds exhibited antibacterial and antifungal activities but at various MIC levels. Compounds Vb, Ve showed potent antibacterial activity against Bacillus subtilis and Pseudomonas aureginosa but have moderate activity on Escherichia coli and Staphylococcus aureus. Compound Vc exhibited moderate activity on all the bacterial strains under study.

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