Orodispersible liquisolid compacts

Vinod Kumar K; Divya K; Harshitha K; Neeraja K; Mobeena MD

doi:10.37022/jpmhs.v8i4.158

Authors

K. Vinod Kumar Professor, Department of Pharmaceutics, St. Ann’s College Pharmacy, Chirala
K.Divya Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala
K.Harshitha Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala
K.Neeraja Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala
MD. Mobeena Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala

DOI:

https://doi.org/10.37022/jpmhs.v8i4.158

Keywords:

Orodispersible liquisolid compacts (ODLSCs), Drug delivery systems, Poorly water-soluble drugs, Bioavailability enhancement, Superdisintegrants, Orodispersible tablets (ODTs)

Abstract

Orodispersible liquisolid compacts (ODLSCs) are an advanced drug delivery system developed by combining the principles of liquisolid technology and orodispersible tablets (ODTs). This innovative approach enhances the dissolution rate and bioavailability of poorly water-soluble drugs while providing rapid disintegration in the oral cavity without the need for water. In a liquisolid system, the drug is dispersed in a non-volatile liquid vehicle and converted into a dry, free-flowing, and compressible powder using suitable carrier and coating materials. The incorporation of superdisintegrants enables the formulation to disintegrate within seconds in the mouth, resulting in a faster onset of action. ODLSCs offer significant advantages for pediatric, geriatric, bedridden, and dysphagic patients who experience difficulty swallowing conventional tablets. Additionally, this system improves patient compliance and may partially bypass first-pass metabolism through pregastric absorption. Despite challenges such as limited drug-loading capacity and sensitivity to moisture, orodispersible liquisolid compacts represent a promising platform for enhancing the therapeutic efficacy of poorly soluble drugs. Their ease of administration, cost-effectiveness, and potential for industrial scalability make them an emerging trend in modern pharmaceutics.

Downloads

Download data is not yet available.

References

Sanka K, Poienti S, Mohd AB, Diwan PV. Improved oral delivery of clonazepam through liquisolid powder compact formulations: in-vitro and ex-vivo characterization. Powder technology. 2014 Apr 1;256:336-44.

Javadzadeh Y, Musaalrezaei L, Nokhodchi A. Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices. Int J Pharm. 2008;362:102-8.

Nokhodchi A, Aliakbar R, Desai S, Javadzadeh Y. Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release. Colloids and Surfaces B: Biointerfaces. 2010 Aug 1;79(1):262-9.

Pavani E, Noman S, Syed IA. Liquisolid technique-based sustained release tablet of trimetazidine dihydrochloride. Drug Invention Today. 2013;5:302-10.

El-Hammadi M, Awad N. Investigating the use of liquisolid compacts technique to minimize the influence of pH variations on loratadine release. AAPS PharmSciTech. 2012;13:53-8.

Badawy MA, Kamel AO, Sammour OA. Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: in vitro and in vivo study. Drug Deliv. 2016;23:818-27.

Suliman AS, Anderson RJ, Elkordy AA. Norfloxacin as a model hydrophobic drug with unique release from liquisolid formulations prepared with PEG 200 and Synperonic PE/L-61 non-volatile liquid vehicles. Powder Technol. 2014;257:156-64.

Spireas S, Bolton SM. Liquisolid systems and methods of preparing same. US Patent 5968550. 1999.

Spireas S. Liquisolid system and method of preparing same. US Patent 6423339B1. 2002.

Spireas SS, Jarowski CI, Rohera BD. Powdered solution technology: principles and mechanism. Pharm Res. 1992;9:1351-8. doi:10.1023/a:1015877905988.

Lu M, Xing H, Jiang J, Chen X, Yang T, Wang D, Ding P. Liquisolid technique and its applications in pharmaceutics. Asian J Pharm Sci. 2017;12:115-23.

Spireas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolid compacts. Int J Pharm. 1998;166(2):177-88.

Reddy M, Babu S, Harshita B, Sravya R. Conventional and patented technologies in oral dispersible tablets: a review. J Chem Pharm Sci. 2012;6(4):286-92.

Kulkarni AS, Aloorkar NH, et al. Liquisolid systems: a review. Int J Pharm Sci Nanotechnol. 2010;3(1):795-802.

Saharan V. Dissolution enhancement of drugs. Part I: technologies and effect of carriers. Int J Health Res. 2009;2(2):107-24.