Soluplus - solid dispersion for enhanced drug delivery
DOI:
https://doi.org/10.37022/jpmhs.v8i3.147Keywords:
Soluplus, Solid dispersion, Drug solubility, Crystallization prevention, Hot-melt extrusion, BioavailabilityAbstract
Many drugs have poor water solubility, which reduces their effectiveness. Solid dispersions are used to enhance the dissolution of such drugs. Soluplus, a polymer, improves drug solubility, prevents crystallization, and enhances absorption. It can be incorporated using techniques such as hot-melt extrusion, spray drying, and solvent evaporation. Incorporating Soluplus in solid dispersions improves drug performance and facilitates better bioavailability.
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Linn M, Collnot EM, Baldes C, Casper J, Rühl-Bagheri I, Schaefer UF, et al. Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo. Eur J Pharm Sci. 2012 Feb;45(3):336–43. doi:10.1016/j.ejps.2011.12.007
Attia MS, Elshahat A, Hamdy A, Fathi AM, Ahmad-Eldin M, Ghazy FES, et al. Soluplus® as a solubilizing excipient for poorly water-soluble drugs: recent advances in formulation strategies and pharmaceutical product features. J Drug Deliv Sci Technol. 2023;84:104534. doi:10.1016/j.jddst.2023.104534
Mahapatra AK, Murthy PN, Biswal S, Mahapatra APK, Pradhan SP. Dissolution enhancement and physicochemical characterization of valsartan in solid dispersions. Int J Pharm Pharm Sci. 2013;5(3):373–80.
Hamma RN, Basha M. Soluplus®: a novel polymeric solubilizer for optimization of carvedilol solid dispersions: formulation design and effect of method of preparation. Powder Technol. 2013;237:406–14. doi:10.1016/j.powtec.2012.12.044
Suresh GA, Anil VM, Dillip JS, Kishor MR, Sonawane RO. Soluplus as a polymeric carrier to enhance solubility, bioavailability, and dissolution of various dosage forms: an overview. Int J Pharm Res Appl. 2024;9(2):1435–42.
BASF. Soluplus®—The first polymeric solubilizer and matrix-forming polymer. BASF Pharma Solutions Monograph. 2010.
Fang J, Chen Z, Song J, Li J, Han Y, Hou W, et al. Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and in vivo antitumor efficacy of hexylselen. RSC Chem Biol. 2021;2(6):1669–77. doi:10.1039/D1CB00089F
Katona G, Sipos B, Ambrus R, Csóka I, Szabó-Révész P. Characterizing the drug release enhancement effect of surfactants on megestrol-acetate-loaded granules. Pharmaceuticals. 2022;15(2):113. doi:10.3390/ph15020113
Rocha TCD, Lima MJD, Nascimento JLN, de Oliveira JF, Silva ED, dos Santos VHB, et al. Development and evaluation of the in vitro schistosomicidal activity of solid dispersions based on indole-hydrazine-carbothiamide derivatives. Exp Parasitol. 2023;256:108626. doi:10.1016/j.exppara.2023.108626
Zhang Y, Ma M, Yang J, Qiu X, Xin L, Lu Y, et al. Preparation, characterization, and oral bioavailability of solid dispersions of Cryptosporidium parvum alternative oxidase inhibitors. Int J Mol Sci. 2024;25(13):7025. doi:10.3390/ijms25137025
Kendre P, Gite M, Jain S. Solubility enhancement of β-ionone with lipidic, amphiphilic, and inclusion complex: extensive polymeric biomaterials to develop formulations for poorly soluble drugs. Polym Bull. 2024;81:14479–98. doi:10.1007/s00289-024-05382-y
Panda UN, Pandi P. Drug director with dosage and indications. Bhubaneswar: PharmaMed Press; 2022.
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