Therapeutic potential of aerva lanata (mountain knotgrass) in the management of urinary tract infections

Authors

  • K.Naga Harikrishna Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.
  • M.Jalaiah Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.
  • S.Laksmi Prasanna Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.
  • J.Varshitha Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.
  • B.Krishna Pardhu Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.
  • K.Ramesh Babu Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.
  • K.Narendra Departmnet of Pharmaccology, QIS College of Pharmacy, Vengamukkapalem, Ongle.

DOI:

https://doi.org/10.37022/jpmhs.v8i3.146

Keywords:

Aerva lanata, urinary tract infections, phytochemicals, ethnomedicine, antibiotic resistance, herbal remedy

Abstract

Urinary tract infections (UTIs) are among the most common bacterial infections, affecting millions globally-especially women. The rising resistance to conventional antibiotics has encouraged the exploration of traditional medicinal plants as alternative therapies. Aerva lanata, commonly known as mountain knot grass, is a well-known herb in traditional Indian and African medicine, often used to treat kidney stones, urinary tract infections, and other urological conditions. This review aims to consolidate current research on the pharmacological properties of Aerva lanata. The plant is rich in phytochemicals such as flavonoids, alkaloids, tannins, saponins, and phenolic compounds, and it exhibits anti-inflammatory, diuretic, and anti-urolithiasis properties. While traditional use and preclinical studies support its therapeutic role in UTIs, further clinical trials are necessary to validate its efficacy, safety, and appropriate dosage in humans. This review brings together current scientific evidence and ethnomedical knowledge, highlighting Aerva lanata as a promising natural remedy for urinary tract infections

Downloads

Download data is not yet available.

References

Gunatilake M, Lokuhetty MD, Bartholameuz NA, Edirisuriye DT, Kularatne MU, Date A. Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract. Pharmacognosy Research. 2012 Oct;4(4):181

Dinnimath BM, Jalalpure SS, Patil UK. Antiurolithiatic activity of natural constituents isolated from Aerva lanata. Journal of Ayurveda and integrative medicine. 2017 Oct 1;8(4):226-

Goyal M, Pareek A, Nagori BP, Sasmal D. Aerva lanata: A review on phytochemistry and pharmacological aspects. Pharmacognosy reviews. 2011 Jul;5(10):195.

Bhanot A, Sharma R, Singh S, Noolvi MN. In vitro anti cancer activity of ethanol extract fractions of Aerva lanata L. Pakistan journal of biological sciences: PJBS. 2013 Nov 1;16(22):1612-7.

Gopalakrishnan S, Chinnappan J. A Way to Treat Kidney Diseases with Plants in Humans. InHerbs for Disease Prevention and Treatment 2024 Nov 7 (pp. 246-264). Bentham Science Publishers.

Gopalakrishnan S, Chinnappan J. A Way to Treat Kidney Diseases with Plants in Humans. InHerbs for Disease Prevention and Treatment 2024 Nov 7 (pp. 246-264). Bentham Science Publishers.

Amarnath S, Narayanan KR, Venkataraman R, Dasarathan P. Anti-diuretic impact of Aerva lanata extracts and their active compounds in furosemide administered diuretic rats. Biotechnol Ind J. 2018;14(6):183

Bansal P, Paul P, Mudgal J, Nayak PG, Pannakal ST, Priyadarsini KI, Unnikrishnan MK. Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice. Experimental and toxicologic pathology. 2012 Sep 1;64(6):651-8.

Bautista EM, Meulenberg JJ, Choi CS, Molitor TW. Structural polypeptides of the American (VR-2332) strain of porcine reproductive and respiratory syndrome virus. Archives of virology. 1996 Jul;141(7):1357-65.

Chen YD, Payne AH. Regulation of testicular LH receptors by homologous hormone. vitro studies on receptor occupancy and receptor loss, Biochem. Biophys. 1977.

Bansal P, Paul P, Mudgal J, Nayak PG, Pannakal ST, Priyadarsini KI, Unnikrishnan MK. Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice. Experimental and toxicologic pathology. 2012 Sep 1;64(6):651-8.

Woldeamanel MM, Senapati S, Mohapatra S, Subudhi H, Rath P, Panda AK. Ethnomedicinal and ethnobotanical investigations and documentation of plants used by traditional healers of eastern India. Current Traditional Medicine. 2022 Dec 1;8(6):2-7

Nussupbekov B, Oshanov Y, Ovcharov M, Mussenova E, Ospanova D, Bolatbekova M. DEVELOPMENT AND CREATION OF A HYDRODYNAMIC LIQUID HEATING UNIT. Eastern-European Journal of Enterprise Technologies. 2022 Nov 15;119(8).

McEwen BS, Gianaros PJ. Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Annals of the New York Academy of Sciences. 2010 Feb;1186(1):190-222=

Merviel P, Heraud MH, Grenier N, Lourdel E, Sanguinet P, Copin H. Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. Fertility and sterility. 2010 Jan 1;93(1):79-88

Butterworth PC, Horsburgh T, Veitch PS, Bell PR, Nicholson ML. Urological complications in renal transplantation: impact of a change of technique. British journal of urology. 1997 Apr;79(4):499-502

Novelli A, Rosi E. Pharmacological properties of oral antibiotics for the treatment of uncomplicated urinary tract infections. Journal of Chemotherapy. 2017 Dec 22;29(sup1):10-8.

Stamm WE, Norrby SR. Urinary tract infections: disease panorama and challenges. The Journal of infectious diseases. 2001 Mar 1;183(Supplement_1):S1-4.

Buttigieg J, Agius-Anastasi A, Sharma A, Halawa A. Early urological complications after kidney transplantation: An overview. World Journal of Transplantation. 2018 Sep 10;8(5):142

Kusbaryanto K, Listiowati L. Risk factors for of urinary tract infection in catheter installation in hospitals. InProceedings International Conference on Sustainable Innovation (ICoSI) 2021 Aug 2 (Vol. 1, No. 1).

Uwaezuoke S, Ayuk A, Muoneke U. Urinary tract infection in children: A review of the established practice guidelines. EMJ Microbiol Infect Dis. 2020;1(1):57-65.

Published

2025-08-31

How to Cite

K, N. H., J. M, L. P. S, V. J, K. P. B, R. B. K, and N. K. “Therapeutic Potential of Aerva Lanata (mountain Knotgrass) in the Management of Urinary Tract Infections”. UPI Journal of Pharmaceutical, Medical and Health Sciences, vol. 8, no. 3, Aug. 2025, pp. 7-15, doi:10.37022/jpmhs.v8i3.146.

Issue

Section

Review Article(s)

Citations

Most read articles by the same author(s)