Evaluation of Invivo Antidepressant and Invitro Antioxidant Activities of Ethanolic Extract of Calendula Officinalis

Abstract

Calendula officinalis, commonly known as marigold, is a well-known medicinal herb used traditionally for its anti-inflammatory, wound healing, and antimicrobial activities. The present study aimed to evaluate the in vivo antidepressant and in vitro antioxidant activities of the ethanolic extract of Calendula officinalis. The antidepressant activity was assessed using standard animal models such as the Forced Swim Test (FST) and Tail Suspension Test (TST) in Wistar albino rats. The extract showed a significant reduction in immobility time, indicating potential antidepressant effects comparable to standard drugs. In vitro antioxidant activity was evaluated through DPPH free radical scavenging and reducing power assays. The extract demonstrated strong antioxidant potential, suggesting the presence of bioactive compounds with free radical neutralizing ability. The findings of this study highlight the dual therapeutic potential of Calendula officinalis in combating oxidative stress and depressive disorders. The presence of flavonoids, phenolics, and other phytoconstituents may contribute to its pharmacological effects. These results support the traditional use of Calendula officinalis in herbal medicine and indicate its promise as a natural source for developing antidepressant and antioxidant therapies. Further studies including isolation of active compounds and clinical trials are warranted. Overall, the study establishes a scientific basis for the medicinal value of this plant extract.