Medicines of Two Worlds: A Scientific Lens Herbal and Modern Therapies
Abstract
The dichotomy between herbal medicine and modern pharmaceutical therapies reflects both a historical continuum and a scientific divergence. Herbal remedies, rooted in traditional systems such as Ayurveda, Traditional Chinese Medicine (TCM), and Unani, rely on plant-based formulations known for their multi-targeted and holistic effects. In contrast, modern drugs are characterized by synthetic origin, molecular precision, and regulatory rigor. This review explores the integration of these two therapeutic paradigms, emphasizing the mechanistic differences, clinical applications, safety profiles, and emerging formulation technologies. Traditional herbal medicine often exhibits synergistic activity via multiple phytoconstituents acting on varied biological pathways. Modern drug development, on the other hand, emphasizes single-compound, receptor-targeted mechanisms. Advances in phytochemistry and analytical techniques have enabled the standardization and scientific validation of many herbal medicines. However, safety concerns, quality control challenges, and herb–drug interactions necessitate cautious integration into modern healthcare systems.The review also highlights progress in nanotechnology and computational modeling, which enhance the bioavailability and predictability of herbal formulations. Global health authorities, including the WHO, advocate for integrative frameworks that combine the benefits of traditional and modern approaches. This integrative model promises improved therapeutic efficacy, lower toxicity, and personalized treatment regimens.
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References
Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001;109(Suppl 1):69–75.
Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 2013;11(2):110–20.
World Health Organization. WHO Traditional Medicine Strategy: 2014–2023. Geneva: WHO; 2013.
Heinrich M, Barnes J, Gibbons S, Williamson EM. Fundamentals of Pharmacognosy and Phytotherapy. 2nd ed. Edinburgh: Elsevier; 2012.
Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine. 2001;8(5):401–9.
Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177.
Calixto JB. The role of natural products in modern drug discovery. An Acad Bras Cienc. 2019;91(Suppl 3):e20190105.
Gertsch J. Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta Med. 2011;77(11):1086–98.
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70(3):461–77.
Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: a comparative overview. Evid Based Complement Alternat Med. 2005;2(4):465–73.
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 2012;3(4):200–1.
Wink M. Modes of action of herbal medicines and plant secondary metabolites. Medicines. 2015;2(3):251–86.
Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45(4):287–306.
Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2006;27(1):1–93.
Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005;78(5):431–41.
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015;33(8):1582–614.
Pandey MM, Rastogi S, Rawat AK. Indian traditional Ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Alternat Med. 2013;2013:376327.
Singh BN, Singh BR, Singh RL, et al. Polyphenolics from various extracts/fractions of red onion (Allium cepa) skin: antioxidant activity, DNA damage protection and antibacterial activity. Food Chem Toxicol. 2009;47(6):1161–7.
Tripathi KD. Essentials of Medical Pharmacology. 8th ed. Jaypee Brothers; 2019.
Shah U, Shah R, Acharya S, Acharya N. Novel drug delivery systems for herbal drugs: an overview. Int J PharmTech Res. 2010;2(1):627–31.
Jain S, Jain PK, Banweer J, Jain D, Sheorey RV. Nanotechnology: A safe and effective drug delivery system. Asian J Pharm Clin Res. 2010;3(3):159–65.
Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv. 2009;27(1):76–83.
Park YH, Kim J, Shin Y, et al. Enhancement of oral bioavailability of poorly soluble drugs using solid dispersions: a review. J Pharm Investig. 2014;44:75–88.
EMA. Guideline on quality of herbal medicinal products. European Medicines Agency. 2011.
U.S. Food and Drug Administration. Guidance for Industry: Botanical Drug Products. 2016.
Patil CR, Jadhav RB, Waghulde H. Network pharmacology: a new approach in drug discovery. PharmaTutor. 2019;7(10):12–7.
Bilia AR, Bergonzi MC, Isacchi B. Phytosomes: advanced herbal drug delivery systems. In: Nutraceutical and Functional Food Regulations in the United States and around the World. 2nd ed. 2014.
Vasanthi HR, Mukherjee S, Das DK. Potential health benefits of broccoli—a chemico-biological overview. Mini Rev Med Chem. 2009;9(6):749–59.
WHO. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. Geneva: WHO; 2000.
Dhami N. Trends in pharmacognosy: a modern science of natural medicines. J Herb Med. 2013;3(4):123–31.
Nair R, Kalariya T, Sumitra C. Antibacterial activity of some selected Indian medicinal flora. Turk J Biol. 2005;29:41–7.
Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. Int Pharm Sci. 2011;1(1):98–106.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1–75.
Singh R, Sharma PK, Malviya R. Pharmacological properties and Ayurvedic value of Indian buch plant (Acorus calamus): A short review. Adv Biol Res. 2011;5(3):145–54.
De Smet PAGM. Herbal remedies. N Engl J Med. 2002;347(25):2046–56.
Sahoo N, Manchikanti P, Dey S. Herbal drugs: standards and regulation. Fitoterapia. 2010;81(6):462–71.
Zhao Y, Zhang Y, Liu J. Application of omics technologies for understanding traditional Chinese medicine. J Ethnopharmacol. 2020;258:112831.
Mukherjee PK, Harwansh RK, Bahadur S, et al. Development of Ayurveda–modern medicine interface: A comparative review of selected botanical preparations. Int J Complement Alt Med. 2017;8(3):00259.
Bodeker G, Ong CK, Grundy C, Burford G, Shein K. WHO Global Atlas of Traditional, Complementary and Alternative Medicine. Geneva: WHO; 2005.
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