PHARMACEUTICAL COCRYSTALS
DOI:
https://doi.org/10.37022/jcls.v9i1.174Keywords:
Solubility Enhancement, Pharmaceutical Cocrystals, Nano Cocrystals, Coformers, Crystallization Techniques, Oral BioavailabilityAbstract
Low aqueous solubility and concomitant oral bioavailability are the major glitches found in converting the active pharmaceutical ingredients to new pharmaceutical products. Many methods are in existence to improve the solubility of poorly water-soluble drugs. Co-crystallization is one of the unique technique that aggregates two or more different chemical entities in a crystalline lattice via non-covalent bonding. Co-crystals are multi-component system of an active pharmaceutical ingredient and a conformer.
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