Development of Simple VU Spectrophotometric Method for the Estimation of Bambuterol Hydrochloride in Bulk and Its Formulations

Ramakrishna M; N Suresh kumar J; Rajeswari R; Nagajyothi T; Jhansi rani M; Aparna CH; Pushpak N

doi:10.37022/jpmhs.v6i2.89

Authors

M Ramakrishna Associate Professor, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Palnadu, A.P
Dr J NSuresh kumar Principal & Professor, Narasaraopet Institute of Pharmaceutical Sciences, Narasaraopet, Palnadu, A.P
R. Rajeswari Research Students, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Palnadu, A.P
T. Nagajyothi Research Students, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Palnadu, A.P
M. Jhansi rani Research Students, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Palnadu, A.P
CH. Aparna Research Students, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Palnadu, A.P
N. Pushpak Research Students, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Palnadu, A.P

DOI:

https://doi.org/10.37022/jpmhs.v6i2.89

Keywords:

Bambuterol hydrochloride, UV Spectrophotometry, Method validation, Distilled water, λmax

Abstract

A simple, rapid and highly sensitive spectrophotometric method has developed for the estimation of Bambuterol hydrochloride in bulk and marketed tablet dosage form. In distilled water, Bambuterol showed absorbance at 264nm. Linearity was observed in the conc range of 200-1000 μg/ml (r²= 0.9990). The assay results were found to be in a good agreement with label claim. The recovery studies were carried at 3 different levels i.e, at 100%, 150%, 200%. The accuracy of the method was conformed by recovery studies of tablet dosage forms and was found to be 96.43% for bambuterol hydrochloride. The method was validated stastically and by good recovery with % RSD is less than 2Thus the proposed method was found to be rapid, specific, precise, accurate and cost-effective quality control tool for the routine analysis of bambuterol hydrochloride in bulk and combined dosage form.

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