Formulation and invivo evaluation of mucoadhesive buccal tablet of fluvastatin sodium

Authors

  • Raja Sekhar Reddy Poonuru Principal and Head, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India
  • Abdul Rasheed Ahmed Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India
  • Rohini Cheruku Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India
  • Pavan Juluri Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India
  • Swetha Sreeramula Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India
  • Akhila Madapu Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India
  • Nethi Harika Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, PIN – 506001, Telangana, India

Keywords:

Buccal Delivery,, Fluvastatin Sodium, Bio adhesion

Abstract

The main objective of this work is to develop mucoadhesive tablet of Fluvastatin sodium, is a sodium salt of a synthetic lipid-lowering agent with potential anti neoplastic activity by employing natural and synthetic polymer and overcome bioavailability related problems and also reduce frequency of administration. Buccal tablets were prepared using HPMC K4M, K15M and Xanthum gum for release retardation, Carbopol 934 for bio adhesion and Chitosan for permeation enhancement. Ethyl cellulose was utilised for backing membrane. It was observed that the release rate slowed down with increasing concentration of carbopol 934 and release rate increased with carbopol 934 and Na CMC from 1:1 to 1:2 ratios in F16 to F 20.NaCMC containing formulations showed better bio adhesion than the HPMC K4M & Carbopol 934.

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References

Adimoolam S, Navinchandra P, Jismon J, Mahin M,Yakinkumar R. Preparation and Evaluation of Timolol Maleate Mucoadhesive Buccal Tablets. International Research Journal of Pharmacy. 2012; 3 (3): 292-297.

Ankarao A, Ch. Babu R and Devanna N. Formulation and Evaluation of Buccoadhesive Bilayered Tablets of Carvedilol. International Journal of Research in Pharmaceutical and Biomedical Science.2012;3 (2):814-818.

Avinash S, Pinkesh P, Bukka R, Jimmy P. Preparation and Evaluation of Buccal Formulation for Triamcinolone. International Journal of Current Pharmaceutical Research. 2011; 3(3): 74-80.

Bagul U, Gujar V, Shalaka D, Sanjeevani A, Bhavsar M. In Vitro Study of Mucoadhesive Strength of Polymers for Mucoadhesive Drug Delivery Systems. International Journal of Current Pharmaceutical Research. 2009;1(1):42-46.

Bhalala C, Nirmal S, Chauhan S, Seth K, Rajnikant V.An Overview on Buccoadhesive Tablet Dosage Form.World Journal of Pharmacy and Pharmaceutical Science.2012;1(4):1054-1076.

Bhaskar U, Rudragouda P, Ravindra B, Swati M, Siddramesh B, Dhananjay A.Formulation and In-VitroEvaluation of Mucoadhesive Buccal Tablets of Furosemide.World Journal of Pharmacy and Pharmaceutical Science.2012;1(3):1041-1063.

ChaudhariAtul L, JagtapLeena S, Mahajan Aniruddha G, Swami Sima P, Mali Prabha R. Formulation and Evaluation of Buccal Tablet of Salbutamol Sulphate. International Research Journal of Pharmacy. 2011; 2 (12): 238-242.

Doijad R., Sompur C.K, Goje A., Maske A. And Tamboli F. Development and Characterization of Lovastatin Controlled Release Buccoadhesive Dosage Form. International Journal of Pharma and Bio Sciences.2011;2(3):133-140.

Ganesh G, Manjusha P, Gowthamarajan K, Suresh R, Senthil V, Jawahar N, Venkatesh N.Design and Development of Buccal Drug Delivery System for Labetalol Using Natural Polymer.International Journal of Pharmaceutical Research & Development. 2011;3(3):37-49.

Hiremath J, Sarfaraz M, Hiremath D, Sarudkar S. Preparation and Physicochemical Characterization of Simvastatin Loaded Mucoadhesive Bilayered Tablet. Indian Journal of Novel Drug Delivery.2009;1(1):18-24.

Izhar Ahmed S, Ravi P and Paul J.Buccal Mucoadhesive Based Drug Delivery Devices. World Journal of Pharmaceutical research. 2012;1(3): 548-575.

Madgulkar A, Kadam S, PokharkarVarsha. Development of trilayered mucoadhesive tablet of Itraconazole with zero-order release. Asian. J. Pharm. Jan. 2008: 57-60.

Mahalaxmi D, Senthil A, Prasad V, Sudhakar B, Mohideen S. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Glipizide. International Journal of Biopharmaceutics. 2010: 1(2): 100-107.

Manasa G., Subramanyam V. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Alfuzosin Hydrochloride. International Journal of Pharma World Research. 2012; 3 (3).

Naga Raju K, Ashok R, Deepika B, Eswaraiah M, Sambasiva A.Formulation And In Vitro Evaluation of Buccal Tablets of Captopril. International Research Journal of Pharmaceutical and Applied Sciences. 2012; 2(2): 21-43.

Narendra T, Burle S, Venkataramana S, Satyavathi B.Studies on Formulation Development and In- Vitro Release Kinetics of Mucoadhesive Buccal Tablets of Secnidazole.International Journal of Pharma World Research.2012; 3(1).

Pankil A, Patel, R. Patel K, M. Patel M. A Review Article on Mucoadhesive Buccal Drug Delivery System. International Journal of Pharmaceutical Research & Development. 2011; 3(5): 159 – 173.

Shah Viral H, Shelat P and Shah Gaurang B. Design and evaluation of thiolated chitosan based mucoadhesive and permeation enhancing bilayered buccal drug delivery system.African Journal of Pharmacy and Pharmacology. 2012; 6(7): 491-501.

Published

2021-09-26

How to Cite

Poonuru, R. S. R., A. R. Ahmed, R. Cheruku, P. . Juluri, S. Sreeramula, A. . Madapu, and H. Nethi. “Formulation and Invivo Evaluation of Mucoadhesive Buccal Tablet of Fluvastatin Sodium”. UPI Journal of Pharmaceutical, Medical and Health Sciences, vol. 3, no. 2, Sept. 2021, pp. 16-25, https://uniquepubinternational.com/journals/index.php/jpmhs/article/view/22.

Issue

Volume-3, Issue-2, 2020

Section

Research Articles(s)
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