DEVELOPMENT AND IN VITRO EVALUATION OF A FLOATING DRUG DELIVERY SYSTEM OF NICORANDIL

Sai Shreeja Alikette; Madhu Chandaka

doi:10.37022/jpmhs.v9i1.191

Authors

Alikette Sai Shreeja Department of Pharmacy, Marri Laxman Reddy Institute of Pharmacy, Dundigal, Hyderabad, Domara Pocham Pally, Telangana 500043
Chandaka Madhu Professor, Department of Pharmacology, Marri Laxman Reddy Institute of Pharmacy, Dundigal, Hyderabad, Domara Pocham Pally, Telangana 500043

DOI:

https://doi.org/10.37022/jpmhs.v9i1.191

Keywords:

Nicorandil, Guar Gum, Almond Gum, Sodium Bi Carbonate, Ceto Sterile Alcohol, Direct Compression Method, Floating Drug Delivery

Abstract

The present study focused on the formulation and evaluation of gastro-retentive floating tablets of Nicorandil designed to provide controlled drug release over a period of 24 hours. The tablets were prepared by direct compression using natural polymers such as almond gum and guar gum to achieve sustained release and floating characteristics. Among all the formulations, batch F5 containing almond gum showed superior performance and was selected as the optimized formulation based on its buoyancy, swelling behavior, drug release profile, and kinetic analysis. The drug release from F5 followed zero-order and Higuchi models, while also fitting well with the Korsmeyer–Peppas equation. Overall, the developed floating tablets enhanced gastric retention, which may contribute to improved bioavailability of Nicorandil.

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