A review of the epidemiology, aetiology, pathogenesis, diagnosis, and current therapies related to colorectal cancer
Keywords:
Colorectal Cancer, Anatomy and physiology, Epidemiology, Risk factorsAbstract
Colorectal cancer (CCR), the third most frequent cancer in the world in both men and women, is the main reason why gastrointestinal cancers result in death. It also comes in second on the list of common causes of cancer-related deaths. The following conditions increase the risk of this cancer: smoking, bad diet, ageing, intestinal inflammatory illnesses, polyps, and heredity. Ninety percent of those who have colorectal cancer are over 50 years old, with a median age of 64. Those with early diagnosis, however, experience a more aggressive course of the illness. About 49,700 fatalities were attributed to it in 2015, according to the American Cancer Association. Reducing the death rate is the aim of early identification and therapy. The prognosis of the patient is currently determined by their survival rate. The immunochemical stool test, guaiac test, sigmoidoscopy, colonoscopy, and barium enema are a few techniques used to diagnose colorectal cancer. To guide future tactics in controlling the disease's burden through population-based preventative programs, more research on colorectal cancer and global advancements is essential.
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Ashizawa S, Brunicardi FC, Wang XP. PDX-1 and the pancreas. Pancreas. 2004 Mar 1;28(2):109-20. https://pubmed.ncbi.nlm.nih.gov/15028942/
Brenner H, Hoffmeister M, Stegmaier C, Brenner G, Altenhofen L, Haug U. Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840 149 screening colonoscopies. Gut. 2007 Nov 1;56(11):1585-9. https://pubmed.ncbi.nlm.nih.gov/17591622/
Kiss S. On-Admission Prognostic Biomarkers and Artificial Intelligence Supported Decision-Making in Medicine (Doctoral dissertation, Szegedi Tudomanyegyetem (Hungary)).
Crockett SD, Barry EL, Mott LA, Ahnen DJ, Robertson DJ, Anderson JC, Wallace K, Burke CA, Bresalier RS, Figueiredo JC, Snover DC. Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial. Gut. 2019 Mar 1;68(3):475-86. https://pubmed.ncbi.nlm.nih.gov/29496722/
Rani TT, Brahmaiah B, Revathi B, Nama S, Baburao C. TARGETING OF ANTI CANCER DRUGS THROUGH NANOPARTICLES.
Dobre M, Dinu DE, Panaitescu E, Bîrlă RD, Iosif CL, Boeriu M, Constantinoiu S, Ivan RN, Ardeleanu CM, Costache M. KRAS gene mutations prognostic factor in colorectal cancer. Rom J Morphol Embryol. 2015 Jan 1;56(2 Suppl):671-8.
Ravella S, Angel M, Subramanian H, Thangavel N, Namballa M, Lokesh D, Mishra AK, Nagaraju GV. Navigating the Future of Cancer Diagnosis: A Comprehensive Review of Novel Approaches for Community-Based Treatment. future.;1:6.
Guyatt GH. A false alarm on red meat and cancer. The Financial Times. 2015 Nov 24.
Pisipati SV, Pathapati H, Bhukya G, Nuthakki S, Chandu B, Nama S, Adeps R. Lycopene: Redress for prostate cancer. Journal of Basic and Clinical Pharmacy. 2012 Mar;3(2):261.
Vennela B, Shirisha V, Rao CB, Gullapalli V, Batsala M. Current and Future Strategies for Therapy of Pancreatic Cancer. International Journal of Research in Pharmacy and Medicine. 2012;2(3):728-40.
Larriba MJ, González-Sancho JM, Barbáchano A, Niell N, Ferrer-Mayorga G, Muñoz A. Vitamin D is a multilevel repressor of Wnt/β-catenin signaling in cancer cells. Cancers. 2013 Oct 21;5(4):1242-60.
Cappell MS. From colonic polyps to colon cancer: pathophysiology, clinical presentation, and diagnosis. Clinics in laboratory medicine. 2005 Mar 1;25(1):135-77.
Meester RG, Mannalithara A, Lansdorp-Vogelaar I, Ladabaum U. Trends in incidence and stage at diagnosis of colorectal cancer in adults aged 40 through 49 years, 1975-2015. Jama. 2019 May 21;321(19):1933-4.
McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ. Circulating vitamin D and colorectal cancer risk: an international pooling project of 17 cohorts. JNCI: Journal of the National Cancer Institute. 2019 Feb 1;111(2):158-69.
Zhang G, Xu Z, Zheng J, Wang M, Ren J, Wei X, Huan Y, Zhang J. Ultra-high b-Value DWI in predicting progression risk of locally advanced rectal cancer: a comparative study with routine DWI. Cancer Imaging. 2023 Jun 12;23(1):59.
Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS. NCCN guidelines insights: colorectal cancer screening, version 1.2018. Journal of the National Comprehensive Cancer Network. 2018 Aug 1;16(8):939-49.
Kumar KR, Nagaraju GV, Subrahmanyam SN, Nagarani K, Shareef S, Tennygilphin M, Namballa M. Assessment on Elements Involving the Academic Performance among Pharmacy Students: A Cross-Sectional Observational Study. Int J Cur Res Rev| Vol. 2021 Dec;13(23):141.
Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Gastroenterology Review/Przegląd Gastroenterologiczny. 2019 Jan 6;14(2):89-103.
Smith RE, Renaud RC, Hoffman E. Colorectal cancer market. Nat Rev Drug Discov. 2004 Jun 1;3(6):471-2.
Siegel RL, Jemal A, Ward EM. Increase in incidence of colorectal cancer among young men and women in the United States. Cancer Epidemiology Biomarkers & Prevention. 2009 Jun 1;18(6):1695-8.
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