Investigation of Lipid Profile Abnormalities in Cardiovascular Disease Patient
Keywords:
Dyslipidemia, Atherosclerosis, Low-density lipoprotein (LDL), Cardiovascular riskAbstract
Background: CHD is a major cause of morbidity and mortality on a global scale and is highly linked with the abnormalities in lipid profile parameters, including cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).
Objective: To evaluate the lipid profile parameters and their association with gender in patients with coronary heart disease
Materials and Methods: This cross-sectional descriptive study was done at Udhyana Institute of Medical Sciences (UIMS), Abbottabad. There were 300 CHD patients (male and female). Blood samples were obtained and lipid profile parameters of total cholesterol, triglycerides, HDL and LDL analysed using standard laboratory procedures.
Results: High cholesterol was found in 13% of male patients and high triglycerides were found in 35% of male patients and high cholesterol in 23% and high triglycerides in 28% of female patients. The levels of HDL varied with 10% of the male population and 12% of the female population having high levels. High LDL levels were seen in 14% of men and 15% of women. The chi-square test showed that there was no statistically significant relationship between gender and the lipid profile parameters (p > 0.05).
Conclusion: CHD patients have dyslipidemia, which is more common in males than in females, but there was no significant gender-specific associations. Lipid abnormalities screening and treatment should be conducted regularly and at an early age to minimize the risk and complications of CHD.
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Shao C, Wang J, Tian J, Tang Y-d. Coronary artery disease: from mechanism to clinical practice. Coronary Artery Disease: Therapeutics and Drug Discovery. 2020:1-36.
Młynarska E, Czarnik W, Fularski P, Hajdys J, Majchrowicz G, Stabrawa M, et al. From atherosclerotic plaque to myocardial infarction—The leading cause of coronary artery occlusion. International Journal of Molecular Sciences. 2024;25(13):7295.
Moss A, Daghem M, Tzolos E, Meah MN, Wang K-L, Bularga A, et al. Coronary atherosclerotic plaque activity and future coronary events. JAMA cardiology. 2023;8(8):755-64.
Trimarco V, Izzo R, Morisco C, Mone P, Virginia Manzi M, Falco A, et al. High HDL (high-density lipoprotein) cholesterol increases cardiovascular risk in hypertensive patients. Hypertension. 2022;79(10):2355-63.
Gospodarczyk A, Marczewski K, Gospodarczyk N, Widuch M, Tkocz M, Zalejska-Fiolka J. Homocysteine and cardiovascular disease—a current review. Wiad Lek. 2022;75(11 pt 2):2862-6.
Khan MSN, Khan MI, Saqlain A, Umer S, Haider M, Ashiq K. Evaluation of Cardiovascular Risk Factors and Their Association With Coronary Artery Disease in Pakistani Adults. Cureus. 2024;16(7):e64670-e.
Florance I, Ramasubbu S. Current understanding on the role of lipids in macrophages and associated diseases. International journal of molecular sciences. 2022;24(1):589.
Abbas A, Raza A, Ullah M, Hendi AA, Akbar F, Khan SU, et al. A comprehensive review: epidemiological strategies, catheterization and biomarkers used as a bioweapon in diagnosis and management of cardio vascular diseases. Current Problems in Cardiology. 2023;48(7):101661.
Yameny A. Lipid profile metabolism, pathophysiology, clinical correlations, and therapeutic strategies in cardiovascular and metabolic diseases. Pharaonic Journal of Science. 2025;1(1):80-91.
Alcover S, Ramos-Regalado L, Girón G, Muñoz-García N, Vilahur G. HDL-cholesterol and triglycerides dynamics: essential players in metabolic syndrome. Antioxidants. 2025;14(4):434.
Naveed A, Atique R, Saeed HA, Sharif J, Haidar A, Samad A. Cardiovascular Diseases: Understanding the Leading Cause of Death Worldwide. Global Journal of Multidisciplinary Sciences and Arts. 2024;1(1):100-10.
Luo C, Tong Y, editors. Comprehensive study and review of coronary artery disease. Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 2023: SPIE.
Pervez A, Mahmud O, Baloch F, Rizvi NA, Bukhari S, Ahmed B, et al. Standardizing the management of cardiovascular diseases in the primary health care setting of Pakistan. BMC Primary Care. 2026;27(1):25.
Ayfokru A, Shewasinad S, Ahmed F, Tefera M, Nigussie G, Getaneh E, et al. Incidence and predictors of mortality among neonates with congenital heart disease in Ethiopia: a retrospective cohort study. BMC pediatrics. 2024;24(1):559.
Martins J, Steyn N, Rossouw HM, Pillay TS. Best practice for LDL-cholesterol: when and how to calculate. Journal of Clinical Pathology. 2023;76(3):145-52.
Cho K-H. The current status of research on high-density lipoproteins (HDL): a paradigm shift from HDL quantity to HDL quality and HDL functionality. International journal of molecular sciences. 2022;23(7):3967.
Lin B, Zhang Z, Zhang W, Zhang C, Xue L, An B, et al. Associations of physical activity types and intensity with cardiovascular diseases by age and gender among 18,730 Chinese adults. Scientific Reports. 2023;13(1):14623.
O’Riordan C, Savage E, Newell M, Flaherty G, Hartigan MSc I. Cardiovascular disease risk factor profile of experienced male amateur marathon runners: a systematic review. Sports Health. 2023;15(5):661-72.
Kwan TW, Wong SS, Hong Y, Kanaya AM, Khan SS, Hayman LL, et al. Epidemiology of diabetes and atherosclerotic cardiovascular disease among Asian American adults: implications, management, and future directions: a scientific statement from the American Heart Association. Circulation. 2023;148(1):74-94.
Hong N, Lin Y, Ye Z, Yang C, Huang Y, Duan Q, et al. The relationship between dyslipidemia and inflammation among adults in east coast China: A cross-sectional study. Frontiers in Immunology. 2022;13:937201.
Taha NM, Mohamed KA, Abd El-Moneam S. Medication Adherence in Patients with Coronary Artery Bypass Grafting.
Faresjö Å, Karlsson J-E, Segerberg H, Lebena A, Faresjö T. Cardiovascular and psychosocial risks among patients below age 50 with acute myocardial infarction. BMC Cardiovascular Disorders. 2023;23(1):121.
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