MUCOADHESIVE DRUG DELIVERY SYSTEM: A PROMISING STRATEGY FOR ENHANCED BIOAVAILABILITY
Keywords:
Mucoadhesion, mucoadhesive drug delivery, polymers, theories and mechanism of mucoadhesion, Factors affecting mucoadhesiveAbstract
Mucoadhesive drug delivery systems (MDDS) have gained considerable attention as an effective approach to address the shortcomings of conventional drug delivery methods, particularly issues such as poor oral bioavailability, rapid drug elimination, and the need for frequent dosing. By adhering to mucosal surfaces, these systems prolong the residence time of dosage forms at the site of absorption, leading to enhanced drug uptake and sustained as well as controlled release profiles. MDDS are formulated using natural or synthetic polymers that interact with mucosal tissues through physicochemical mechanisms including hydrogen bonding, electrostatic interactions, and polymer chain interpenetration.
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