A Rare but Aggressive Renal Manifestation of IgA Vasculitis in an 11-Year-Old Girl

Abstract

Although rare, crescentic Henoch–Schönlein purpura (HSP) nephritis poses a significant diagnostic and therapeutic challenge due to its variable clinical presentation and unpredictable disease course. Crescentic HSP nephritis is a severe manifestation accounting for less than 5% of HSP nephritis cases and is associated with rapid deterioration of renal function, potentially progressing to end-stage renal disease if not promptly treated. Early diagnosis, close monitoring, and timely recognition of complications are essential for initiating appropriate management and preserving renal function. Lifestyle modifications, including dietary regulation and physical activity, may contribute to symptom control and improvement in overall health. Renal involvement in HSP typically presents with hematuria and mild to moderate proteinuria; however, crescentic involvement represents a more aggressive pathological variant requiring intensive therapy.