Project Assistant, CSIR-Indian Institute of chemical Technology (IICT), Hyderabad, Telangana- 500088, India.
The main objective of the present study was to explore the feasibility of time dependent pulsatile drug delivery system (PDDS) of Valsartan (VLSN) for the treatment of hypertension. The core tablet formulations were prepared by direct compression method and optimized core tablet formulation was coated by press coating technique. The immediate release core tablets consist of VLSN and some other disintegrants in different ratios with the drug concentration. Coating layer consists of Hydroxy Propyl Methyl Cellulose (HPMC), Ethyl Cellulose (EC), Guar gum (GG) and Xanthan gum (XG) as release retarding polymers in varying ratios. The obtained results of pre and post compression parameters were complied with the official limits. The core tablet formulation F5 was optimized based on the results obtained from disintegration and dissolution studies. Polymer ratio of 1:1 (HPMC: EC) showed a desired lag time of 7 h. The desired lag time of 7 h was satisfied by the formulation CF4 and showed the maximum drug release of 98%. The increase in HPMC concentration showed decrease in lag time and vice versa in the case of EC.
Key words: Chronodrug delivery, Direct compression, Hypertension, Lag time, Valsartan.