Neutrophil Extracellular Traps: Missed Link Between Atherosclerosis and Diabetes Mellitus
Professor & Senior Consultant of Therapeutic Unit, Internal Medicine Department, State Medical University for Zaporozhye, 26, Mayakovsky av., Zaporozhye, Postcode 69035, Ukraine.
Diabetes mellitus (DM) is a metabolic disease with high risk of atherosclerosis including peripheral artery disease (PAD). Although developing of PAD associates with plaque accumulation, early stages of type 2 DM (T2DM)-induced vaculopathy closely relates to hyperglycemia, lipotoxicity, oxidative stress, impaired vascular repair, endothelial dysfunction, and microvascular inflammation. Neutrophil extracellular trap (NET) known as NETosis is an important component of innate immune system that has been actively investigated for the last two decades. NETosis is a link between systemic / microvascular inflammation and atherosclerosis, which contributes to accumulation of pro-atherogenic factors and cell debris in circulation and thereby mediate progression of the PAD. The opinion is depicted the role of NETosis in pathogenesis of vascular complications in T2DM.
Key words: Diabetes mellitus, Peripheral artery disease, Atherosclerosis, Neutrophil extracellular trap, Inflammation.