Correlation of Inflammatory markers C-Reactive Protein and Interleukin 6 with Visfatin in Chronic Kidney Disease Patients
Nosheen Mahmood1*, Rashid Awan2, Muhammad Saqib3, Humera Akhlaq4, Saima Amir1
1Lecturer Pathology, King Saud Bin Abdul Aziz University, Kingdom of Saudi Arabia.
2Internal Medicine, Ministry of Health Madina Al Munawara, Kingdom of Saudi Arabia.
3Scientific Assistant, Karachi Institute of Radiotherapy and Nuclear Medicine, Pakistan.
4Assistant Professor Oral Pathology, Jinnah Sind Medical University, Pakistan.
Inflammation and oxidative stress have a significant contribution in pathogenesis of chronic kidney disease. Visfatin, an adipocytokine has been proposed as a pro inflammatory cytokine. In this study, we evaluated correlation of serum visfatin with inflammatory markers C - reactive protein (CRP) and IL-6 in chronic kidney disease patients. Serum visfatin, IL-6 and CRP levels were measured in 80 subjects including 30 healthy controls and 50 diagnosed patients of CKD. Subjects with a history of any autoimmune or chronic joint disease and fever within last 2 months were not included in this study. Visfatin concentration was significantly high in patients with CKD compared to controls (8.7 ± 4.7 vs 5.2± 3.3 p< 0.001). We found positive correlation of Visfatin with CRP (r=0.256, p<0.01) and IL-6 (r=0.756, p<0.01). Serum Visfatin correlated positively with CRP and IL-6 which suggests its association with inflammation in chronic kidney disease however; further studies at molecular level may clarify mechanism of inflammation in CKD.
Key Words: Visfatin, C - reactive protein, Inflammation, Chronic kidney disease.