Immunomodulatory and anti-inflammatory properties of an orally bioavailable sod-gliadin complex


  • Eric Postaire Académie nationale de Pharmacie, 4 avenue de l’Observatoire, F75006 Paris, France
  • Laurent Intes Isocell, 53 rue du Général Marcial Vallin, F75015 Paris, France
  • François Vix Isocell, 53 rue du Général Marcial Vallin, F75015 Paris, France



Superoxide dismustase, Gliadin, Anti-inflammatories activities, Immunomodulatory properties, fibrosis, antioxidant


Superoxide Dismutase (SOD) constitutes part of the body’s front line in antioxidant defenses, helping to maintain the physiological oxidant-antioxidant balance. However, this balance can be disrupted by a number of factors that include aging, smoking, pollution, exposure to sunlight, high intensity exercise, infection and the subsequent immune response. The body experiences oxidative stress under these types of conditions, which has been linked to the increased risk of chronic disease. Oral supplementation of the enzyme, in order to boost the body’s antioxidant defense system, has been ineffective due to the biochemical conditions experienced as the enzyme passes through the gastrointestinal tract. This passage degrades the enzyme, rendering it useless. This publication reviews the science related to GliSODin®, a trade name for SOD extracted from cantaloupe melon and combined with wheat gliadin. Clinical research and scientific evidence is presented to demonstrate that gliadin protects SOD during passage through the stomach, thus allowing absorption of the SOD enzyme once inside the intestine.


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How to Cite

Eric, P., I. . Laurent, and V. François. “Immunomodulatory and Anti-Inflammatory Properties of an Orally Bioavailable Sod-Gliadin Complex”. UPI Journal of Pharmaceutical, Medical and Health Sciences, vol. 5, no. 4, Dec. 2022, pp. 68-74, doi:10.37022/jpmhs.v5i4.84.



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