Tridax procumbens pharmacological activities-An updated review

Syed Sagheer  Ahmed; Rupesh Kumar  Mani; Sai Kiran; Bharathi  D R; Athulya shaji; Aldona Sunny; Anjuna  Raveendran

doi:10.37022/jpmhs.v4i3.27

Authors

Syed Sagheer Ahmed Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka
Rupesh Kumar Mani Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka
Sai Kiran Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka
Bharathi D R Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka
Athulya shaji Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka
Aldona Sunny Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka
Anjuna Raveendran Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Mandya Dist, Karnataka

DOI:

https://doi.org/10.37022/jpmhs.v4i3.27

Keywords:

Tridax procumbens, subtropical and mild temperate regions

Abstract

Tridax procumbens is also known as coat buttons belongs to family Asteraceace. It is the important medicinal plant which is mainly found in central and South America. It is also seen in tropical, subtropical and mild temperate regions worldwide. It is a flowering plant and widespread weed that contains several medicinal values. The whole plant extract is used as drug. Tridax procumbens has been described to use as antidiabetic, antioxidant, hepatoprotective, wound healing. It is also used in the treatment of infectious skin diseases, liver disorders and kidney stone diseases. The major active constituents of this plant are flavanoids, alkaloids, saponins, tannins, terpenes, kaempferol and isoquercetin. Traditionally it has been used for treating blisters, ulcer, jaundice, respiratory problems and gastritis.

Downloads

Download data is not yet available.

References

Kondawar VB. A comprehensive review on phytochemistry and pharmacological use of Tridax procumbens Linn. Journal of Pharmacognosy and Phytochemistry. 2019;8(4):01-10.

Ghosh P, Biswas S, Biswas M, Dutta A, Sil S, Chatterjee S. Morphological, Ethno biological and Phytopharmacological Attributes of Tridax procumbens Linn.(Asteraceae): A Review. Int. J. Sci. Res. in Biological Sciences Vol. 2019 Apr;6:2.

Beck S, Mathison H, Todorov T, Calder EA, Kopp OR. A review of medicinal uses and pharmacological activities of Tridax procumbens (L.). Journal of Plant Studies. DOI. 2018;10.

Kumar S, Prasad A, Iyer SV, Vaidya S. Pharmacognostical, phytochemical and pharmacological review on Tridax procumbens Linn. International Journal of Pharmaceutical & Biological Archives. 2012;3(4):747-51.

D.A. Bhagwat, S.G. Killedar, R.S. Adnaik,"Anti- diabetic activity of leaf extract of Tridax procumbens”, Intnl. J. Green Pharma,Vol. 2, Issue. 2, pp. 126-28, 2008.

Caceres, A., López, B., González, S., Berger, I.,Tada, I., Maki, J. (1998). Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plants. J. Ethnopharmacol., 62(3), 195-202.

Sawant, R., & Godghate, A. (2013). Preliminary phytochemical analysis of leaves of Tridax procumbens Linn. International Journal of Science, Environment and Technology, 2(3), 388-394.

Kumar, L., Prasad, A., Iyer, S., & Vaidya, S. (2012). Pharmacognostical, phytochemical and pharmacological review on Tridax procumbens. International Journal of Pharmaceutical & Biological Archives, 3(4), 747-751.

Ikewuchi, J. C. (2012). Alteration of Plasma Biochemical, Haematological and Ocular Oxidative Indices of Alloxan Induced Diabetic Rats by Aqueous Extract of Tridax procumbens Linn (Asteraceae). EXCLI Journal, 11, 291-308.

Policegoudra, R. S., Chattopadhyay, P., Aradhya, S. M., Shivaswamy, R., Sing, L., & Veer, V. (2014). Inhibitory effect of Tridax procumbens against human skin pathogens. Journal of Herbal Medicine, 4(2), 83-88.

Jindal, A., & Kumar, P. (2012). Antimicrobial activity of alkaloids of Tridax procumbens L. against human pathogens. International Journal of Pharmaceutical Sciences and Research, 3(9), 3481-3485.

Saxena, M., Mir, A. H., Sharma, M., Malla, M. Y., Qureshe, S., Mir, M. I., & Chaturvedy, Y. (2013). Phytochemical screening and in-vitro antioxidant activity isolated bioactive compounds from Tridax procumbens Linn. Pak J. Biol. Sci., 16(24), 1971-1977.

Tiwari, U., Rastogi, B., Singh, P., Saraf, K., & Vyas, S. (2004). Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals. Journal, 92(1), 113-119.

Saxena, M., Mir, A. H., Sharma, M., Malla, M. Y., Qureshe, S., Mir, M. I., & Chaturvedy, Y. (2013). Phytochemical screening and in-vitro antioxidant activity isolated bioactive compounds from Tridax procumbens Linn. Pak J. Biol. Sci., 16(24), 1971-1977.

Kethamakka, S. R. P., & Deogade, M. S. (2014). Javanti veda (Tridax procumbens) unnoticed medicinal plant by Ayurveda. Journal of Indian System of Medicine, 2(1), 6-20.

Saxena, V., & Albert, S. (2005). Β-Sitosterol-3-O-β-D-xylopyranoside from the flowers of Tridax procumbens Linn. Journal of Chemical Sciences, 117(3), 263-266.

Jhariya, S., Rai, G., Yadav, A. K., Jain, A. P., & Lodhi, S. (2015). Protective effects of Tridax procumbens Linn. Leaves on experimentally induced gastric ulcers in rats. Journal of Herbs, Spices & Medicinal Plants, 21(3).

Manjamalai, A., Kumar, M. M., & Grace, V. M. B. (2012a). Essential Oil of Tridax procumbens L induces apoptosis and suppressed angiogenesis and lung metastasis of the B16F-10 cell line in C57BL/6 mice. Asian Pacific J Cancer Prev., 13(11), 5887-5895.

Kamble, S. I., & Dahake, P. R. (2015). Preliminary phytochemical investigation and study on antimicrobial activity of Tridax Procumbens Linn. International Refereed Multidisciplinary Journal of Contemporary Research, 2(3), 388-394.

Sonawane A, Srivastava RS, Sanghavi N, Malode Y, Chavan B. Anti-diabetic activity of Tridax procumbens. Journal of Scientific and Innovative Research. 2014;3(2):221-6.

Vishnu Priya P, Radhika K, Siva Kumar R, Sri Ramchandra M, Prameela Devi Y, Srinivas Rao A. Evaluation of anti-cancer activity of Tridax procumbens flower extracts on PC 3 Cell lines. Pharmanest. 2011;2(1):28-30.

Ravishankara MN, Shrivastava N, Padh H, Rajani M. Evaluation of antioxidant properties of root bark of Hemidesmus indicus R. Br.(Anantmul). Phytomedicine. 2002 Jan 1;9(2):153-60.

Chander R, Khanna AK, Raj K, Rastogi AK. Antioxidant and lipid lowering activities of Indian black tea. Indian Journal of Clinical Biochemistry. 2005 Jan 1;20(1):153.

Taddei A, Rosas-Romero AJ. Bioactivity studies of extracts from Tridax procumbens. Phytomedicine. 2000 Jun 1;7(3):235-8.

Udupa SL, Udupa AL, Kulkarni DR. Influence of Tridax procumbens on lysyl oxidase activity and wound healing. Planta Medica. 1991 Aug;57(04):325-7.

Christudas S, Kulathivel TM, Agastian P. Phytochemical and antibacterial studies of leaves of Tridax procumbens L. Asian pacific journal of tropical Biomedicine. 2012 Jan 1;2(1):S159-61.

Manjamalai A, Kumar MJ, Grace VM. Essential oil of Tridax procumbens L induces apoptosis and suppresses angiogenesis and lung metastasis of the B16F-10 cell line in C57BL/6 mice. Asian Pacific Journal of Cancer Prevention. 2012;13(11):5887-95.

Ravikumar V, Shivashangari KS, Devaki T. Hepatoprotective activity of Tridax procumbens against d-galactosamine/lipopolysaccharide-induced hepatitis in rats. Journal of Ethnopharmacology. 2005 Oct 3;101(1-3):55-60.

Tiwari U, Rastogi B, Singh P, Saraf DK, Vyas SP. Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals. Journal of Ethnopharmacology. 2004 May 1;92(1):113-9.

Oladunmoye MK, Nutan Modi M, Dezzutti CS, Kulshreshtha S, Rawat A, Srivastava S. Immunomodulatory effects of ethanolic extract of Tridax procumbens on swiss Albino rats orogastrically dosed with Pseudomonas aeruginosa (NCIB 950). Int J Trop Med. 2006;1(4):152-5.

Udupa AL, Kulkarni DR, Udupa SL. Effect of Tridax procumbens extracts on wound healing. International Journal of Pharmacognosy. 1995 Jan 1;33(1):37-40.

Diwan PV, Iravati K, Margaret I, Sattur PB. Pharmacology and biochemical evaluation of Tridax procumbens on inflammation. Indian journal of pharmacology. 1989 Apr 1;21(2):1.

Prabhu VV, Nalini G, Chidambaranathan N, Kisan SS. Evaluation of anti inflammatory and analgesic activity of Tridax procumbens Linn against formalin, acetic acid and cfa induced pain models. Int J Pharm Pharm Sci. 2011;3(2):126-30.

Syed Sagheer A, Chandra Prakash K, Saba Tabassum, Noor Salman, Ahalya Devi K H. Influence of Various Solvent Extracts of Tridax procumbens for its Antidiarrhoeal Potential. Journal of Pharmaceutical sciences and research. 2019;11(10):3497-3500.

Appiah-Opong R, Nyarko AK, Dodoo D, Gyang FN, Koram KA, Ayisi NK. Antiplasmodial activity of extracts of Tridax procumbens and Phyllanthus amarus in in vitro Plasmodium falciparum culture systems. Ghana Medical Journal. 2011;45(4).

Jhample, S. B., Gajdhane, S. B., Kasabe, P. J., Bhagwat, P. K., & Dandge, P. B. (2015). Phytochemical screening and in vitro antimicrobial activity of Tridax procumbens L. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, June, 44-56.

Pai, C., Kulkarni, U., Borde, M., Murali, S., Mrudula, P., & Deshmukh, Y. (2011). Antibacterial activity of Tridax procumbens with special reference to nosocomial pathogens. British Journal of Pharmaceutical Research, 1(4), 164-173.

Petchi, R. R., Parasuraman, S., & Vijaya, C. (2013). Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats. Journal of Basic and Clinical Pharmacy, 4(4), 88-92.

Vishnu, P., Radhika, K., Siva, R., Ramchandra, M., Prameela, Y. A., & Srinivas, R. (2011). Evaluation of anti-cancer activity of Tridax procumbens flower extracts on PC 3 cell lines. Pharmanest - An International Journal of Advances In Pharmaceutical Sciences, 2(1), 28-30.

Ravikumar, V., Shivashangari, K. S., & Devaki, T. (2005a). Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced in D-galactosamine sensitized rats. Mole. Cell Biochem, 269(1-2), 131-136.

Ravikumar, V., Shivashangari, K. S., & Devaki, T. (2005b). Hepatoprotective activity of Tridax procumbens against d-galactosamine-lipopolysaccharide-induced hepatitis in rats. J. Ethnopharmacol, 101(1-3), 55-60.

Patel, N. A., Vaidya, S. K., Kumar, S., Prasad, A. K., & Bothara, S. B. (2014). Antioxidant and hepatoprotective activity of extracts of flowers of Tridax procumbens Linn, against Dgalectosamine induced hepatotoxicity in male Wister albino rats. IAJPR 4(49), 3712-3720.

Adjagba, M., Awede, B., Nondichao, K., Lagnika, L., Osseni, R., Darboux, R., Laleye, A. (2015). Antihypertensive activity of different fractions of Tridax procumbens crude aqueous extract in wistar rats. Journal of Physiology and Pharmacology Advances, 5(9), 713-719.

Habila, J. D., Bello, I. A., Dzikwi, A. A., Musa, H., & Abubakar, N. (2010). Total phenolics and antioxidant activity of Tridax procumbens Linn. African Journal of Pharmacy and Pharmacology, 4(3), 123-126.

Han, R. M., Zhang, J. P., & Skibsted, L. H. (2012). Reaction Dynamics of Flavonoids and Carotenoids as Antioxidants. Molecules, 17(2), 2140-2160.

Manjamalai, A., & Grace, V. M. B. (2004). Effect of essential oil of Tridax procumbens Linn on in-vivo antioxidant level in cancer model and in-vitro free radical scavenging activity. International Journal of Pharmaceutical Analysis, 37(10), 261-271.

Jachak, S. M., Gautam, R., Selvam, C., Madhan, H., ASrivastava, A., & Kah, T. (2017). Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L. Fitoterapia, 82, 173-177.

Tiwari, U., Rastogi, B., Singh, P., Saraf, K., & Vyas, S. (2004). Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals. Journal, 92(1), 113-119.

Martín-Quintal, Z., Moo-Puc, R., González-Salazar, F., Chan-Bacab, M. J., Torres-Tapia, L. W., Peraza-S, L. W., & Torres-Sanchez, S. R. (2009). In vitroactivity of Tridax procumbens against promastigotes of Leishmania mexicana. J. Ethnopharmacol., 122(3), 463-467.

Taddei, A., & Rosas-Romero, A. J. (2000). Bioactivity studies of extracts from Tridax procumbens. Phytomedicine, 7(3), 235-238.

Dhanabalan, R., Doss, A., Jagadeeswar, M., Balanchandar, S., Kezia, E., Parivuguna, V., Reena Josephine, C. M., Vaidheki, R., & Kalamani, K. (2008). In vitro phytochemical screening and antibacterial activity of aqueous and methanolic leaf extracts of Tridax procumbens against bovine mastitis isolated Staphylococcus aureus. Ethnobotanical Leaflets, 12, 1090-1095.

Ali, M., Ravinder, E., & Ramachandram, R. (2001). Phytochemical communication: A new flavonoid from the aerial parts of Tridax procumbens. Fitoterapia, 72(3), 313-315.

Appiah-Opong, R., Nyarko, A. K., Dodoo, D., Gyang, F. N., Koram, K. A., & Ayisi, N. K. (2011). Antiplasmodial activity of extracts of Tridax procumbens and Phyllanthus amarus in in vitro Plasmodium falciparum culture system. Ghana Med J., 45(4), 143-150.

Ghosh P, Biswas S, Biswas M, Dutta A, Sil S, Chatterjee S. Morphological, Ethno biological and Phytopharmacological Attributes of Tridax procumbens Linn.(Asteraceae): A Review. Int. J. Sci. Res. in Biological Sciences Vol. 2019 Apr;6:2.

A. Jayashree, M. Sivaprakasam, “Studies on the antibacterial activity of the extracts from Tridax procumbens L and Ixora coccinea L”, Biomedicine,Vol. 28, Issue. 3, pp. 190-94, 2008.

G. Babu, Sanjeeva, K. L. Bairy, “Effect of Tridax procumbens on burn wound healing”, Indian Drugs, Vol. 40, Issue. 8, pp. 488-91, 2003.

P.V.Diwan, L.D.Tilloo, D.Kulkarni, “Influence of Tridax procumbens on wound healing”, Indian J. Med Res, Vol. 75, pp. 450-54, 1982.

Gaikwadi, Vadlamudi, V.P. Waghmaee, S.P. Maral, V.J. Ranteke, V.D. Dhok, “Phytochemical analysis of aqueous extract of few medicinal plants”, Journal of Ethnopharmacology, Vol. 2, pp. 91-92, 2003.

S. Mundada, R. Shivhare, “Pharmacology of Tridax procumbens”, International Journal of Green Pharmacy, Vol. 5, pp. 91-94, 2008.

A. Jain and A. Jain, “Tridax procumbens(L): A weed with Immense Medicinal Importance: A Review”, International Journal of Pharma and BioSciences, Vol. 3, Issue. 1, pp. 544-52, 2012.

S.L. Udupa, A.L. Udupa, DR. Kulkarni, “India Plantamedica”, Indian Journal of Pharmaceutical Sciences, Vol. 57, pp. 325-27, 1991.

B. Sailaja, K. Bharathi, K.V.S.R.G. Prasad, “Protective effect of Tridax procumbens L. on Calcium Oxalate Urolithiasis and oxidative stress”, An International Journal of Advances in Pharmaceutical Sciences, Vol. 2, pp. 9-14, 2011.