A contemporary review on phytochemistry and pharmacology of Andrographis paniculata
DOI:
https://doi.org/10.37022/jpmhs.v4i1.25Keywords:
Andrographis paniculata, Acanthaceae, Siddha, Ayurveda, homeopathyAbstract
Andrographis paniculata is a well-known medicinal plant that belongs to the Acanthaceae family and is also commonly known as "Kalmegh or king of bitters". It is a bitter herb used in Siddha, Ayurveda, and homoeopathy medicines, as well as tribal medicines in india and other countries. This article describes the synonyms, biological sources, phytoconstituents and various pharmacological activities of Andrographis paniculate includes Anti-inflammatory activity, hepatoprotective, antidiabetic, anticancer, antibacterial, antimalarial, antivenom, analgesic, antifertility, antioxidant, antidiarrhoel, neuroprotective, cardioprotective, antiviral and Nephroprotective activities.
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Mathew G, Joy PP, Skaria BP, Mathew S. Cultivation prospects of tuberous medicinal plants. InNational Seminar on Achievements and Opportunities in Postharvest Management and Value Addition in Root and Tuber Crops (NSRTC 2), Centre for Tuber Crops Research Institute (CTCRI), Thiruvananthapuram, India 2005 Jul (pp. 81-82).
Akbar S. Andrographis paniculata: a review of pharmacological activities and clinical effects. Alternative Medicine Review. 2011 Mar 1;16(1):66-77.
Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S. Anticancer and immunostimulatory compounds from Andrographis paniculata. Journal of ethnopharmacology. 2004 Jun 1;92(2-3):291-5.
Sudhakaran MV. Botanical pharmacognosy of Andrographis paniculata (Burm. F.) Wall. Ex. Nees. Pharmacognosy Journal. 2012 Nov 1;4(32):1-0
Sharma N, Sharma O, Garg N. REVIEW OF ANDROGRAPHIS PANICULATA (BURM. F).
Akbar S. Andrographis paniculata: a review of pharmacological activities and clinical effects. Alternative Medicine Review. 2011 Mar 1;16(1):66-77.
Lakshmi V, Agarwal SK, Mahdi AA. AN OVERVIEW OF ANDROGRAPHIS PANICULATA (BURM. F.) NEES.
Mishra SK, Sangwan NS, Sangwan RS. Andrographis paniculata (Kalmegh): a review. Pharmacognosy Reviews. 2007;1(2).
Kataky A, Handique PJ. A brief overview on Andrographis paniculata (Burm. f) Nees., a high valued medicinal plant: Boon over synthetic drugs. Asian J Sci Technol. 2010 Oct;6:113-8.
Subramanian R, Asmawi MZ, Sadikun A. A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata. Phytochemistry reviews. 2012 Mar;11(1):39-75
Kour N. Andrographis paniculata: A review on ethnomedicinal potential and biological activities. Journal of Plant Development Sciences. 2016;8(1):1-6.
Rajasekaran A, Arivukkarasu R, Mathew L. A systematic comprehensive review on therapeutic potential of Andrographis paniculata (Burm. f.) Wall. ex Nees. Journal of Pharmacognosy and Phytochemistry. 2016 Sep 1;5(5):189
Grover M. Green Chiryata (Andrographis paniculata): A potential blood purifier..
Siripong P, Kongkathip B, Preechanukool K, Picha P, Tunsuwan K, Taylor WC. Cytotoxic diterpenoid constituents from Andrographis paniculata Nees leaves. J Sci Soc Thailand. 1992 Dec 1;18(4):187-94
Niranjan A, Tewari SK, Lehri A. Biological activities of kalmegh (Andrographis paniculata Nees).
Sheeja K, Shihab PK, Kuttan G. Antioxidant and anti-inflammatory activities of the plant Andrographis paniculata Nees. Immunopharmacology and immunotoxicology. 2006 Jan 1;28(1):129-40.
Rajalakshmi G, Jothi KA, Venkatesan R, Jegatheesan K. Hepatoprotective activity of andrographis paniculata on paracetamol induced liver damage in rats. Journal of Pharmacy Research. 2012 Jun;5(6):2983-6
Hossain MA, Roy BK, Ahmed K, Chowdhury AS, Rashid MA. Antidiabetic activity of Andrographis paniculata. Dhaka University Journal of Pharmaceutical Sciences. 2007;6(1):15-20..
Rajeshkumar S, Nagalingam M, Ponnanikajamideen M, Vanaja M, Malarkodi C. Anticancer activity of andrographis paniculata leaves extract against neuroblastima (IMR-32) and human colon (HT-29) cancer cell line. World Journal of Pharmacy and Pharmaceutical Sciences. 2015 Apr 15;4(6):1667-75.
Mishra PK, Singh RK, Gupta A, Chaturvedi A, Pandey R, Tiwari SP, Mohapatra TM. Antibacterial activity of Andrographis paniculata (Burm. f.) Wall ex Nees leaves against clinical pathogens. journal of pharmacy research. 2013 May 1;7(5):459-62
Balu S, Alagesaboopathi C. Antivenom activities of some species of andrographis wall. Ancient science of life. 1995 Jan;14(3):187.
Shivaprakash G, Gopalakrishna HN, Padbidri DS, Sadanand S, Sekhar SS, Shetty RN. Evaluation of Andrographis paniculata leaves extract for analgesic activity. Journal of Pharmacy Research. 2011;4(10):3375-7.
Zoha MS, Hussain AH, Choudhury SA. Antifertility effect of andrographis paniculata in mice. Bangladesh Med Res Counc Bull. 1989 Jun;15(1):34-7. PMID: 2818412.
Premanath R, Devi NL. Antibacterial, antifungal and antioxidant activities of Andrographis paniculata Nees. Leaves. International Journal of Pharmaceutical Sciences and Research. 2011 Aug 1;2(8):2091
Misra P, Pal NL, Guru PY, Katiyar JC, Srivastava V, Tandon JS. Antimalarial activity of Andrographis paniculata (Kalmegh) against Plasmodium berghei NK 65 in Mastomys natalensis. International Journal of Pharmacognosy. 1992 Jan 1;30(4):263-74.
Sivananthan M, Elamaran M. Medicinal and pharmacological properties of Andrographis paniculata. Int J Biomol Biomed 2013b. 2013;3(2):1-2.
Awang K, Abdullah NH, Hadi AH, Su Fong Y. Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts. Journal of Biomedicine and Biotechnology. 2012 Oct;2012.
Rajendrakumar T, Rao S, Satyanarayana ML, Narayanaswamy HD, Byregowda SM. Effect of Andrographis paniculata on cisplatin induced renal histopathology in Wistar albino rats.
Nagajothi S, Mekala P, Raja A, Raja MJ, Senthilkumar P. In ovo antiviral activity of Andrographis paniculata against NDV2K35 strain of Newcastle disease virus. Journal of Pharmacognosy and Phytochemistry. 2020;9(4):2023-9.
Yang EJ, Song KS. Andrographolide, a major component of Andrographis paniculata leaves, has the neuroprotective effects on glutamate-induced HT22 cell death. Journal of Functional Foods. 2014 Jul 1;9:162-72.
Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tandon JS. Immunostimulant agents from Andrographis paniculata. Journal of Natural products. 1993 Jul;56(7):995-9.
Tiwari DK, Yadav A. Ethnobotanical investigation of some medicinal plants availed by Gond tribe of Naoradehi wild life sanctuary, Madhya Pradesh. The Anthropologist. 2003 Jul 1;5(3):201-2.
Ayyanar M, Ignacimuthu S. Medicinal plants used by the tribals of Tirunelveli hills, Tamil Nadu to treat poisonous bites and skin diseases.
Ayyanar M, Sankarasivaraman K, Ignacimuthu S. Traditional herbal medicines used for the treatment of diabetes among two major tribal groups in South Tamil Nadu, India. Ethnobotanical leaflets. 2008;2008(1):32.
Poonam K, Singh GS. Ethnobotanical study of medicinal plants used by the Taungya community in Terai Arc Landscape, India. Journal of ethnopharmacology. 2009 May 4;123(1):167-76.
Vijayalakshme R, Ranganathan R. Ethnobotanical studies among villagers from Cuddalore District, Tamil Nadu, India. J. Pharm. Res. 2011 Sep;4(9):3083-8.
BELGICA TH, Suba M, Alejandro GJ. Quantitative ethnobotanical study of medicinal flora used by local inhabitants in selected Barangay of Malinao, Albay, Philippines. Biodiversitas Journal of Biological Diversity. 2021 Jul 3;22(7).
Mya Z, Mu AA, Myint ZM, Aye T, Aung SS, Jianwitchayakul P. Quantitative ethnobotanical study of medicinal plants used by Karen people of Wah-Theinkha village in Kawmhu Township, Myanmar. Interdisciplinary Research Review. 2021 Feb 27;16(1):18-22
Grover M. Green Chiryata (Andrographis paniculata): A potential blood purifier..
ELFRIDA E, TARIGAN NS, Suwardi AB. Ethnobotanical study of medicinal plants used by community in Jambur Labu Village, East Aceh, Indonesia. Biodiversitas Journal of Biological Diversity. 2021 Jul 3;22(7).
Prabhu S, Vijayakumar S, Yabesh JM, Prakashbabu R, Murugan R. An ethnobotanical study of medicinal plants used in pachamalai hills of Tamil Nadu, India. Journal of Herbal Medicine. 2021 Feb 1;25:100400.
Pandey AK. An Ethnobotanical Study of Medicinal Plants in Atal Nagar (New Raipur) of Chhattisgarh, India.
Boopathi CA. Andrographis spp.: a source of bitter compounds for medicinal use. Ancient science of life. 2000 Jan;19(3-4):164.
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